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Biomedicum Genomics Oy
support@bmgen.fi
Haartmaninkatu 8
FI-00290 Helsinki
Finland
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Research and Product Development
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Research
Biomedicum Genomics (BMGen) develops functional genomics technologies for
different biomedical and pharmaceutical applications and conducts research
projects as contract research in collaboration with academic and industrial
partners. Our current research activities are focused on cancer research
and application of functional genomics technologies to identify biological
and therapeutic targets in cancer.
The Biomedicum Genomics leadership is actively engaged in scientific
research publishing in major scientific journals (see highlighted
publications below).
Product Development
We are actively developing new products and services for functional
genomics purposes. We offer high quality services in copy number and gene
expression microarray profiling and in virus mediated gene silencing and
overexpression.
We aim to expand our services by continuously developing new components to
the currently offered basic products and by increasing our product
portfolio. For the moment our viral product development includes improving
virus production efficiency, automating virus production and defining novel
quality controls. These enhancements will enable us to serve clients with
even higher titer and better quality viral particles and increase
throughput. BMGen has an access to a variety of shRNA and ORF constructs,
which we have available both in-house and on request from commercial
vendors. We are also diversifying our products range in biochip technology
and are optimizing sample preparation procedures for deep sequencing.
Highlighted Publications
artanen JI, Nieminen AI, Klefstrom J (2009) 3D view to tumor suppression:
Lkb1, polarity and the arrest of oncogenic c-Myc. Cell Cycle
8(5):716-24
Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi
S, Monni O (2008) Deciphering downstream gene targets of PI3K/mTOR/p70S6K
pathway in breast cancer. BMC Genomics 9:348
Myllykangas S, Junnila S, Kokkola A, Autio R, Scheinin I, Kiviluoto T,
Karjalainen-Lindsberg ML, Hollmén J, Knuutila S, Puolakkainen P, Monni O
(2008) Integrated gene copy number and expression microarray analysis of
gastric cancer highlights potential target genes. Int J Cancer
123(4):817-25
Järvinen AK, Autio R, Kilpinen S, Saarela M, Leivo I, Grénman R,
Mäkitie AA, Monni O (2008) High-resolution copy number and gene
expression microarray analyses of head and neck squamous cell carcinoma
cell lines of tongue and larynx. Genes Chromosomes Cancer
47(6):500-9
Nieminen AI, Partanen JI, Klefstrom J (2007) c-Myc blazing a trail of
death: coupling of the mitochondrial and death receptor apoptosis pathways
by c-Myc. Cell Cycle 6(20):2464-72
Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J (2007) Suppression of
oncogenic properties of c-Myc by LKB1-controlled epithelial organization.
Proc Natl Acad Sci U S A 104(37):14694-9
Nieminen AI, Partanen JI, Hau A, Klefstrom J (2007) c-Myc primed
mitochondria determine cellular sensitivity to TRAIL-induced apoptosis.
EMBO J 26(4):1055-67
Järvinen AK, Autio R, Haapa-Paananen S, Wolf M, Saarela M, Grénman R,
Leivo I, Kallioniemi O, Mäkitie AA, Monni O (2006) Identification of
target genes in laryngeal squamous cell carcinoma by high-resolution copy
number and gene expression microarray analyses. Oncogene
25(52):6997-7008
Järvinen AK, Hautaniemi S, Edgren H, Auvinen P, Saarela J, Kallioniemi
OP, Monni O (2004) Are data from different gene expression microarray
platforms comparable? Genomics 83(6):1164-8
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